PP55. ANALYSIS OF SEPARATE AND COMBINATORIAL ABERRATIONS OF EGFR, C-MYC, ZNF217 AND CCND1 GENES IN LARYNX CANCER
D. KOYNOVA1, V. Tsenova2, K. Kunev3 and D. Toncheva1 1. Department of Medical Genetics, Medical University, Sofia, Bulgaria 2. Department of Pathology, University Hospital "Queen Joanna", Sofia, Bulgaria 3. Department of Head and Neck, University Hospital "Queen Joanna", Sofia, Bulgaria e-mail: dragatoncheva@yahoo.com
*Corresponding Author:
page: 72

Abstract

The aim of the present study was to establish the frequency of separate and combinatorial copy number changes of EGFR, C-MYC, ZNF217 and CCND1 in larynx cancer. The impact of these aberrations on tumor stage, metastatic potential and tumor grade was considered. A total of 240 larynx tumor samples, included in a preexisting tissue microarray were successfully hybridized by fluorescent in situ hybridization for all 4 loci. Normal gene copy numbers of all loci were established in 71 tumors (29.58%). In 169 tumors (70.42%) at least one aberration was observed. The frequency of aberrations was significantly associated with a higher risk for the development of metastasis (p< 0.0002). In addition, higher frequency of aberrations was detected in stage IV tumors (71.43%) in comparison with stage I-III tumors (59.32%, p= 0.13). Single abnormalities were detected in 90 tumors (53.25%), while double or higher changes were found in 79 tumors (46.75%). The single abnormalities neither the combinatorial ones when analyzed separately showed an association with tumor stage, metastatic potential or tumor grade. We conclude that EGFR, C-MYC, ZNF217 and CCND1 aberrations play an important role in larynx tumorigenesis related to invasive tumor potential.




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