PP53. PREFERENTIAL LOCALIZATION OF LOW GRADE GLIOMAS WITH INCREASED MGMT AND P53 EXPRESSION
EREN P.1, Uyar S.2, Kılıç T.3, Topuzoğlu A.4, Erdağ B.5, Sav A2, Pamir M.N 3, Çırakoğlu B1 1. Marmara University Department of Medical Biology and Genetics 2. Marmara University Institute of Neurological Sciences Department of Pathology, 3. Marmara University Department of Neurosurgery, 4. Marmara University Department of Public Health, 5. Scientific and Technical Research Council of Turkey, Marmara Research Center e-mail: pinaren@yahoo.com; pinaren@gmail.com
*Corresponding Author:
page: 71

Abstract

Anatomical localization of gliomas are important for surgical excision of the tumour mass totally. The most important factor effecting prognosis is left tumour tissue mass that is effected by the localization and its total excision is only possible when the tumour is suitable for surgical intervention. Low grade gliomas are preferentially located at the secondary motor areas and especially oligodendrogliomas are located at the frontal and temporal lobes. Fourtyeight cases of this study were composed of 12 Astrocytomas, 16 Oligodendrogliomas and 20 Oligoastrocytomas histopathologically and 22 patients of the total group had p53 mutations. P53 protein expression of all three histopathological groups has found to be increased in mutation positive specimens than in non-mutated specimens at a statistically significant level. In this study the tumours having high MGMT expression those expected to be chemoresistant are located mostly at the parietal and temporal regions (p=0.029). The tumours with increased p53 exspression preferentially were located at the frontal and temporal lobes (p=0,014). With the detection of MGMT and p53 expression at the glial tissue, anticipation of theraphy modality and prognosis of the patients could be possible. Key Words; Localization of low grade gliomas, MGMT expression, p53 expression, prognosis.




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