IMPACT OF GENETICS ON NEOADJUVANT THERAPY WITH COMPLETE PATHOLOGICAL RESPONSE IN METASTATIC COLORECTAL CANCER: CASE REPORT AND REVIEW OF THE LITERATURE
Bulajic P1, Bidzic N1,*, Djordjevic V1, Ceranic M1,2, Basaric D1,2, Pesic V3, Djordjevic-Pesic J4
*Corresponding Author: Nemanja Bidzic, M.D., Clinic for Digestive Surgery, Clinical Center of Serbia, Koste Todorovica 6, Belgrade 11000, Serbia. Tel. +381-11-306-5957. Fax: +381-11-306-5967. E-mail: nemanja bidzic@yahoo.com
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CONCLUSIONS

There are literature data on similar efficiency of combined cytotoxic and biological therapy, especially in the neoadjuvant setting, as well as on its impact on long-term survival. Genetic mutations as biomarkers have a crucial role in the management of colorectal cancer stage IV, with KRAS mutation status being significant in the choice of neoadjuvant molecular targeted therapy. Our study has shown that Bevacizumab-containing neoadjuvant treatment can have rather promising results for both metastatic and primary colorectal cancer. Pathological complete response is associated with better overall survival and should be evaluated in future research. We conclude that modern cancer therapy must be individualized, multimodal and based on a genetic cancer profile. Declaration of Interest. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.



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