ASSOCIATION BETWEEN INHERITED THROMBOPHILIA IN PREGNANCY AND MICRONUCLEUS FREQUENCY IN PERIPHERAL BLOOD LYMPHOCYTES
Šošić GM, Jović N2, Rakić B, Dimitrijević A, Varjačić M
*Corresponding Author: Gordana M. Šošić, B.Sc., Department of Cytogenetic Diagnosis, Obstetrics and Gynecology Clinic, Clinical Center “Kragujevac,” 30 Zmaj Jovina Street, 3400 Kragujevac, Serbia. Tel: +381-63-835-66-24. Fax: +381-34-37-00-73. Email: gordana.sosic.2011.02@gmail.com
page: 5

CONCLUSIONS

It can be concluded that the frequency of micronuclei >4MN/1000BN depends on the presence of thrombophilia, previous miscarriages, the number of miscarriages and the number of pregnancies. The presence of thrombophilia in pregnancy in the study group is the most important pre dictor variable of increased MN frequency. Based on the current knowledge, we hypothesize that the DNA damage, measured by the increase in frequency of MN, probably occurs as a result of oxidative stress initiated by prothrombotic condition in the mother’s blood.



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