ASSOCIATION BETWEEN OSTEOPROTEGERIN GENE POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Jia P, Wu N, Jia D, Sun Y
*Corresponding Author: Professor Dalin Jia and/or Professor Yingxian Sun, Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, People’s Republic of China. Tel: +86-242-326-9477. Fax: +86-242-326-9477. Email: jdl2001@126.com and/or yxsun@mail.cmu.edu.cn
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INTRODUCTION

Coronary artery disease (CAD), especially acute myocardial infarction, is becoming one of the major causes of morbidity and mortality worldwide [1]. Multiple factors, such as genetic variants, lifestyle and environmental factors, are believed to be involved in the occurrence and progression of CAD [2-4]. In recent years, more and more researchers carry out large scale genomewide association studies (GWAS) to elucidate the pathogenesis of CAD at the gene expression level and the results have demonstrated that gene polymorphisms are strongly associated with the susceptibility to CAD [5,6]. Osteoprotegerin (OPG), a new member of the tumor necrosis factor (TNF) receptor superfamily, has been identified as a soluble non-transmembrane glycoprotein secreted by osteoblasts (OCs) [7]. It plays a key role in the formation and resorption of bone through inhibiting differentiation and maturation of OC and inducing OC apoptosis [8]. In addition, OPG is also an important vascular modulator and strongly linked with the occurrence and progression of atherosclerosis and arteriosteogenesis [9]. More importantly, OPG has been associated with the presence and severity of CAD, as evidenced by elevated serum OPG concentrations in CAD patients [10,11]. The gene encoding OPG is located on the long arm of chromosome 8 at position 24. Some recent studies have shown that the T950C and G1181C polymorphisms of the OPG gene are associated with vulnerability of CAD [12- 15], but the sample size was relatively small and the results were controversial [16]. Therefore, in the present study, we performed a meta-analysis to evaluate the association between OPG gene polymorphisms and the risk of CAD.



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